NUCLEOFILL STRONG:  an innovation in aesthetic and anti-aging medicine. 


Nucleofill is a product based on active polynucleotides specially designed for skin renewal and bio-restructuring. Nucleofill is a bio-revitalizing product. It is compatible with a mesotherapy protocol. This product is not intended for volume.

This innovative treatment acts on three levels:

  • Facelift
  • Antioxidant
  • Moisturizing.

Nucleofill Strong provides a significant and lasting rejuvenating effect. 


Nucleofill is an innovation in aesthetic and anti-aging medicine  due to its polynucleotide-based skin bio-stimulation technique. The polynucleotides contained in NUCLEOFILL Medium stimulate cell renewal in an effective, long-lasting and preventive way.

1- Receptors on skin fibroblasts.

With such stimulation, they transform into myofibroblasts. The production of type I collagen and elastin is stimulated, which results in a thickening and lifting of the skin.

2- Trap free radicals

Nucleofill medium provides a powerful antioxidant action.


3- Binding to water molecules

The polynucleotides bind to water and provide long-term isosmotic hydration of the extracellular matrix. 

The skin gains in deep hydration and firmness.

Indications for Nucleofill Strong:

Skin subject to oxidative stress, lack of oxygen

Dehydrated skin

Stretch marks



– Nucleofill contains no sugars or proteins minimizing the risk of allergies.

– Nucleofill is available in two doses (Nucleofill Medium 20 mg / ml and Nucleofill Strong 25 mg / ml), its choice depends on the skin condition, it does not depend on age.


Nucleofill is designed for all skin types, regardless of its maturity:

– Visible rejuvenating effect without affecting facial features

– Reduces the appearance of wrinkles and creases and firms the skin

– Skin exposed to oxidative stress (due to air pollution, sun exposure, smoking, poor diet)

– Dehydrated skin

– Before injections, to extend their aesthetic effects



Nucleofill – 30G needles are recommended. The choice of needle and the injection procedure are determined by the treating doctor.

Manufacturer – PromoItalia

Polynucleotide gel at 2.5%

1.5 ml syringe pH between 6.8 and 7.5 viscosity 48-65 PA * S 2 needles 30G 13MM in each box


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